Sudha Seshadri, M.D., is professor of neurology at UT Health San Antonio and founding director of the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases.She has been an investigator at the FHS since 1998, leading the clinical neurology and neurogenetics cores since 2005.Additionally, she completed her residency in neurology at the BUSM and a fellowship in the Neurobiology of Aging and Alzheimer Disease at the University of Massachusetts Medical Center and the FHS.She is a senior investigator in the Brainstorm consortium, which is conducting genome-wide association studies of 25 disorders including Alzheimer's disease, stroke, major depressive disorder, epilepsy and schizophrenia.She is currently investigating the impact of midlife obesity, as well as different dietary, inflammatory and neurotrophic biomarkers, in association with stroke, cognitive function, MRI markers of abnormal brain aging and dementia.She has lectured extensively nationally and internationally on Alzheimer's disease, dementia and the genetics of stroke and vascular brain injury.
Events - Primer's event detection algorithm clusters and summarizes multiple documents describing real-world events.
Mentions - Mentions are snippets of text that map to a person.
Docs - The number of documents that match to a person in Primer's corpus of news articles.
Full tech explainer here.
Remember to check the sources and follow Wikipedia's guidelines.
Boston University School of Medicine
Looking at a group of 5,205 people who were older than 60 and who had regular tests of their cognitive function for decades, Dr. Sudha Seshadri and her colleagues found that dementia declined on average by 20% each decade from the 1970s to the 2000s. Only people with a high school education or more showed such declines, however, and dementias related to problems with circulation showed the sharpest declines. That makes sense, say she, since dementia is connected to problems in circulation, and the Framingham Heart Study looks at risk factors for heart disease, which include circulation-related factors such as blood pressure and stroke. She says the Framingham Study data did not include good information on the people's exercise habits in the 1970s, so she wasn't able to analyze how physical activity patterns changed and whether they affected the incidence of dementia. It's possible that lifestyle factors such as physical activity and diet, as well as taking care of heart disease risk factors like hypertension, may all contribute to preventing dementia.
Previous studies have looked mainly at genes causing hardening of the arteries, known as atherosclerosis, and those behind blood clots that cause a form of the disease called ischaemic stroke. No previous study has identified a gene for the common type of small vessel disease stroke although some genes associated with a form of the condition that runs in families, such as CADASIL, are known. Professor Sudha Seshadri, of Boston University, said: "Our research has identified a gene affecting another type of ischaemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischaemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries. "Unraveling the mechanisms of small vessel disease is essential for the development of therapeutic and preventive strategies for this major cause of stroke."
Sugary soft drinks are killing your brain — and diet versions are even worse! Two new studies done by the same team of Boston University researchers revealed a "very strong suggestion" that not only do sugary soft drinks shrink the human brain and reduce memory capacity but sugar-free versions lead to higher chances of stroke and dementia. "There is not very much of an upside to having sugary drinks, and substituting the sugar with artificial sweeteners doesn't seem to help," said Sudha Seshadri, a BU professor of neurology and senior author of both studies. The findings will affect, well, pretty much everyone; Americans consumed 24 billion pounds of sugar last year, most of it in drinks, federal statistics show.