Kalin is the Hedberg Professor and chair of the Department of Psychiatry at the University of Wisconsin School of Medicine.He was trained at Thomas Jefferson Medical College, UW Hospital and Clinics and the National Institutes of Mental Health.He is a Distinguished Fellow of the APA and has served on the APA Council on Research.His work focuses on developing a basis of early intervention for children at risk of developing long-term anxiety.The research stems from work he has done in monkeys, including a controversial study that started last year after he dropped one of the most contentious parts: removing newborn monkeys from their mothers to study the effect that had on their level of anxiety.There he runs a laboratory, which combines molecular, preclinical animal models, and human functional imaging studies to understand the neurobiology underlying anxiety and mood disorders.
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UW School of Medicine and Public Health
"Over-activity of these three brain regions are inherited brain alterations that are directly linked to the later life risk to develop anxiety and depression,'' says senior author Dr. Ned Kalin, chair of psychiatry at the UW School of Medicine and Public Health. Previous research by his group has shown that anxious temperament is inherited, and explained the brain circuits involved. To understand which brain regions are responsible for passing anxiety from generation to generation, the authors measured anxiety-related behavior with high-resolution functional and structural brain imaging. Although the search for the genetic underpinnings of anxiety have thus far been elusive, this research helps explain how genes might affect brain function and lead to extreme childhood anxiety, which greatly increases the risk to develop anxiety and depressive disorders.
The research provides new insights into the risk and development of anxiety disorders. Using brain imaging techniques regularly employed in human studies, Ned Kalin and colleagues found that functional connectivity between two regions of the central extended amygdala is associated with anxious temperament in pre-adolescent rhesus macaques. As extreme early-life is a risk factor for and depression in humans, further study of this nonhuman primate model may yield new directions in the prevention of these disorders in at-risk children.