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Matthew D. Disney

Matthew D. Disney is affiliated with the Scripps Research Institute.[1]He is a member of Department of Chemistry.[1]

He earned his B.S. at the University of Maryland and both his M.S. and Ph.D. at the University of Rochester, before completing a postdoctoral fellowship at the Massachusetts Institute of Technology and the Swiss Federal Institute of Technology in Zurich, Switzerland.[2]Dr. Disney is a full professor in the bi-coastal Department of Chemistry at The Scripps Research Institute with laboratories on the Florida campus of TSRI.[2]His group has developed broad approaches to the directed use of RNA genome sequence to inform the development of lead small-molecule medicines for multiple conditions with unprecedented potency and selectivity.[3]His research has now been published in the Journal of the American Chemical Society.[4]His research focuses on RNA-based drug discovery.[5]His work has also garnered many awards, including the NIH Director's Pioneer Award, the Tetrahedron Young Investigator Award, the James Watson Investigator Award and others.[6]

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Scripps Research Institute

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Scientists hope to use a disease's own genetic makeup to fight against it

While the development has only been tested in rat models, researchers have been able to design a drug that decreases the growth of tumor cells in triple negative breast cancer, one of the most difficult forms of the disease to treat. "The study represents a clear breakthrough in precision medicine, as this molecule only kills cancer cells that express the cancer-causing gene – not healthy cells," said Prof. Matthew Disney, a researcher at The Scripps Research Institute where the drug was designed. "These studies may transform the way the lead drugs are identified – by using the genetic makeup of a disease." This method for fighting disease involves inserting certain compounds or molecules into the disease's structure to disrupt harmful activity. For example, the drug created to fight triple negative breast cancer, called Targaprimir-96, causes breast cancer cells to kill themselves by targeting a specific RNA. The researchers believe that this new method of developing precise drug candidates can be a huge improvement over existing therapies, which can kill cells indiscriminately or cause harmful side effects.[78]

2016-05-10

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