Dr. Barney Graham is the deputy director of the Vaccine Research Center.Graham at National Institutes of Health - he's at the National Institute of Allergy and Infectious Diseases, which is part of the NIH in Bethesda, Md.The Vaccine Research Center, where Graham is deputy director, was the brainchild of Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases.
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The study showed that the vaccine, given at three different doses, triggered an immune response in the people who received it. Graham: These kinds of proteins are important for the virus to enter cells. So what we're giving is not really like the virus, but it makes this viral protein.
“I just let it all go,” Graham said. If custom-designed RNA snippets could be used to turn cells into bespoke protein factories, messenger RNA could become a powerful medical tool. Weissman had done a fellowship in Fauci’s laboratory at NIH, studying the immune cells involved in vaccine responses. He asked Kariko if she could make some RNA for an HIV vaccine idea he was pursuing.