Luk H Vandenberghe

Luk H Vandenberghe is affiliated with the Harvard Medical School.[1]He/She specializes in ophthalmology.[2]

Luk Vandenberghe is an inventor on Anc80 and other gene transfer technologies, for which he receives royalties.[3]He is director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear and assistant professor of ophthalmology at Harvard Medical School.[4]He completed his doctorate on the structural basis of AAVs in 2007 at the Catholic University of Leuven in Belgium, and later went on to become an associate professor at Harvard University in Cambridge, Massachusetts.[5]His work on developing and improving numerous vector delivery systems has already proved innovative and useful for efficacy and safety in a number of therapeutic applications.[1]He also is a founder, board member, and advisor to Odylia Therapeutics, a non-profit catalyzing translation for gene therapies within the challenging field of ultra-rare disorders.[6]Dr. Vandenberghe has over 50 peer reviewed publications and more than a dozen licensed patents, mostly related to gene therapy methods, technologies, and applications.[6]

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Grousbeck Gene Therapy Center


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Recent events

AAV COVID-19 vaccine aims for the sweet spot between antibody and T cell immunity

The academic team behind the only AAV vaccine candidate for COVID-19 thinks its vector can get the best of both worlds and induce stronger antibody responses than adenoviral vaccines, while still activating T cells. Adenoviruses, a leading modality among COVID-19 vaccines, “are great T cell vaccines, but actually quite meek B cell vaccines,” said Luk Vandenberghe, director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear. He believes that AAVs, a vector class more commonly used for gene therapies, can be leveraged to strongly activate both B and T cells against COVID-19.[12]


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Celtics co-owner Wyc Grousbeck makes big donation to coronavirus vaccine efforts in Mass.

Celtics co-owner Wyc Grousbeck has made a $1 million donation toward efforts to develop a COVID-19 vaccine at a pair of Massachusetts hospitals. Eye and Ear are joining forces to work on developing an approved vaccine for the novel coronavirus. The hospitals' new project is simply the latest among several in Boston working toward a coronavirus vaccine and at least 111 worldwide, according to the Globe. According to Luk Vandenberghe, director of the Grousbeck Gene Therapy Center, the effort has received several million dollars in total funding.[13]


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Now Hear This

Now the researchers report restoring a much higher level of hearing—down to 25 decibels, the equivalent of a whisper—using an improved gene therapy vector developed at Massachusetts Eye and Ear. Eye and Ear; and Luk Vandenberghe, HMS assistant professor of ophthalmology at Mass. Eye and Ear who led the development of Anc80 in 2015. Since patients—and mice—with Usher 1C also have balance problems caused by hair-cell damage in the vestibular organs, the researchers also tested whether gene therapy restored balance.[91011]


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